Cancer Research UK has reported that its scientists have developed a very comprehensive method of predicting a women’s risk of developing breast cancer.
This work was recently published in Genetics in Medicine where it was explained that by combining information on family history, genetics and other factors like weight, age at menopause, alcohol consumption and use of hormone replacement therapy, scientists are able to determine a woman’s breast cancer risk.
What makes their prediction more precise than previous methods is that researchers, for the first time, included 300 genetic indicators for breast cancer in their risk calculation.
This piece of work has led to the development of an online calculator that General Practitioners (GPs) in the UK can use in their surgeries. Currently this online calculator is being tested by GPs, nurses and genetic counsellors before it is released nation-wide. The hope is that this tool will enable healthcare professionals to explore early detection and prevention strategies for women based on their risk and therefore improve survival rates for breast cancer.
Although this work is very exciting more work is needed, as expressed by lead author, Professor Antonis Antoniou, who said:
“It could be a game changer for breast cancer because now we can identify large numbers of women with different levels of risk – not just women who are at high risk.
This should help doctors to tailor the care they provide depending on their patients’ level of risk. For example, some women may need additional appointments with their doctor to discuss screening or prevention options and others may just need advice on their lifestyle and diet.
“We hope this means more people can be diagnosed early and survive their disease for longer, but more research and trials are needed before we will fully understand how this could be used.”
Additionally, Dr Richard Rope, Cancer Research UK’s GP expert warned that:
“Research like this is hugely exciting because in the future it will enable us to offer much more tailored care which will benefit patients and make best use of the services that we have available.
“Although having an increased risk of breast cancer means a woman is more likely to develop the disease – it’s by no means a certainty. A woman at high risk may never get breast cancer just as a woman at low risk still could. But any woman with concerns should speak to her GP to discuss the options.”
For more information on this work, you can read Cancer Research UK’s research paper here
