Over the past month, as we have been conducting our regular monitoring of the traffic to our website, we have noticed a lot of visitors are coming to our website to find out whether soursop or guava are beneficial for fibroids. So, today, we will visit published research to see if we can answer this question.

 How We’re Going to Approach This Question

The first thing to say about this topic is there isn’t a lot of evidence-based information out there. What we found were discussions by scientists about the possibilities, there wasn’t any concrete data that could definitively answer this question.

To explore whether guava and soursop may be beneficial in treating fibroids, we will focus on one scientific paper, which was the only one we could find that was related to this topic.

This paper was published by the Department of Experimental and Clinical Medicine at the Polytechnic University of Marche in Italy, in 2014.

Their paper, the ‘Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: Promising options for prevention and treatment of uterine fibroids?,’  is a review of a  selection of substances (phytochemicals) found naturally in certain fruits and vegetables which, because of their properties, could be useful in treating and preventing fibroids.

This paper is important in our exploration because some of the phytochemicals included in the researchers’ review are found in soursop and guava.

Some Background: What are Phytochemicals?

Before we summarise the relevant information provided in this paper, we thought it would be useful to define the term phytochemical. Harvard University describes phytochemicals as:

”…plant (phyto) chemicals: compounds in plants (fruits, vegetables, whole grains, nuts, seeds, and legumes) that contribute to their color, taste, and smell.”

Some commonly known phytochemicals are carotenoids, found in carrots, pumpkin, corn and tomatoes; flavonoids, found in citrus fruits, berries, apples and legumes and anthocyanins, which are found in berries, eggplant and red cabbage.

It is widely known that phytochemicals have a range of health benefits. These benefits include reducing our risk of heart disease, cancer and other chronic diseases and this is achieved because of their antioxidant and anti-inflammatory effects as well as a range of other effects.

What Does This Research Paper Tell Us?

The researchers who wrote this paper began their exploration by describing four possible factors that contribute to the development of fibroids. These are:

• A chronically active inflammatory immune response
• Fibrosis (a process that leads to the formation of scar tissue) which is a result of inflammation
• Increased rate of cell growth in fibroid cells
• The development of new blood vessels which feed fibroid cells

Researchers explained that if phytochemicals are able to address these four factors, they may be useful in preventing and treating fibroids.

Like many fruits, guava and soursop are rich in phytochemicals.  Guava is known to contain the phytochemicals lycopene, quercetin, anthocyanin, and many others.  Whilst soursop contains reticuline, coreximine, quercetin, gallic acid and others.

In their paper, researchers discuss a range of phytochemicals including ones that are relevant to guava and soursop – lycopene and quercetin. They explain that at the time of the publication of their paper, lycopene and quercetin have not been tested in fibroids, but based on what scientists know about these two chemicals they may be beneficial in the prevention and treatment of fibroids.  This is because when we look back at the four possible ways that fibroids develop, these two phytochemicals can potentially target these processes. They have both been found to have the following effects:

• An anti-inflammatory effect
• Anti-fibrotic effect
• Prevent the growth of different types of tumour cells (fibroids are benign tumours)
• Prevent the development of blood vessels that feed tumour cells

Researchers couldn’t make any conclusions on these phytochemicals with regards to fibroids, but their discussion has identified these and other phytochemicals which could be beneficial in the prevention and treatment of fibroids. These include:

• Allicin (found in garlic)
• Ellagic acid (found in strawberries, raspberries, cranberries, blackberries, pecans, pomegranates, walnuts, wolfberry and grapes)
• Indole-3-carbinol (found in cruciferous vegetables e.g. broccoli, cabbage, cauliflower, Brussel sprouts, bok choy, collard greens, kale etc.
• Lycopene (found in tomato, watermelon, papaya, pink guava, pink grapefruit and apricots)
• Quercetin (found in lemon, tomato, onion leaves, strawberries, soursop and tea)

They stated that based on the information they presented, there is a need to understand whether these phytochemicals are indeed beneficial for fibroids and this should be explored through future studies that carefully and accurately determine their mechanism of action and effectiveness in the treatment and prevention of fibroids.

What Does this Mean for Women With Fibroids?

This research study has raised the idea that the phytochemicals in soursop and guava may be beneficial in the treatment and prevention of fibroids. It doesn’t mean that eating soursop and guava will cure your fibroids, the reason for this, and this is discussed in the research paper, is that when you eat these fruits we don’t know if your body is absorbing enough of these phytochemicals to have a significant impact on the growth and development of fibroids.

What we can say is that if you have fibroids, if you haven’t already, we recommend that you adopt a healthy diet that is rich in fruits and vegetables, this can include soursop and guava, but should include cruciferous vegetables.  Studies have shown that making dietary changes can be helpful in improving some of the symptoms of fibroids as can introducing more exercise into your routine.

It is also recommended that women with fibroids avoid certain foods such as alcohol, caffeine, red meat and foods that may contain high levels of hormones like oestrogen.

If you have fibroids and would like to explore dietary changes and exercise as a way of managing your symptoms, please speak to your doctor first. She/he will be able to advise you on the best approach based on your specific situation as the success of these approaches will depend on the size of your fibroids and other factors.  You may also want to speak to a registered dietitian who along with your doctor will be able to provide some advice on the dietary changes that you can make.

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References

1. Agu KC, Okolie PN. Proximate composition, phytochemical analysis, and in vitro antioxidant potentials of extracts of Annona muricata(Soursop). Food Sci Nutr. 2017;5(5):1029-1036. Published 2017 Jun 29. doi:10.1002/fsn3.498
2. Chiari-Andréo, Bruna & Trovatti, Eliane & Marto, Joana & Almeida-Cincotto, Maria & Melero, Ana & Corrêa, Marcos & Chiavacci, Leila & Ribeiro, Helena & Garrigues, Teresa & Isaac, Vera. (2017). Guava: Phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications. Brazilian Journal of Pharmaceutical Sciences. 53. 10.1590/s2175-97902017000216141.
3. Deepa PC., Kumaria IR., and Lavanya B. (2015) Phytochemical Analysis, Antioxidant and Anti Microbial Activity of White and Pink Psidium Guajava Linnaeus. International Journal of Current Pharmaceutical Research, 7(2), pp 29-31.
4. Harvard Health Publishing., (2019). Fill up on phytochemicals [Online]. Harvard Medical School. [Viewed on 4^th July 2020]. Available from: https://www.health.harvard.edu/staying-healthy/fill-up-on-phytochemicals
5. Islam MS, Akhtar MM, Ciavattini A, et al. Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids? Mol Nutr Food Res. 2014;58(8):1667-1684. doi:10.1002/mnfr.201400134
6. Jacoby VL, Jacoby A, Learman LA, et al. Use of medical, surgical and complementary treatments among women with fibroids. Eur J Obstet Gynecol Reprod Biol. 2014;182:220-225. doi:10.1016/j.ejogrb.2014.09.004
7. Leitzmann C. Characteristics and Health Benefits of Phytochemicals. Forsch Komplementmed. 2016;23(2):69-74. doi:10.1159/000444063
8. Shen Y, Wu Y, Lu Q, Ren M. Vegetarian diet and reduced uterine fibroids risk: A case-control study in Nanjing, China. J Obstet Gynaecol Res. 2016;42(1):87-94. doi:10.1111/jog.12834